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Immunoglobulin binding (B1) domain mediated antibody conjugation to quantum dots for in vitro and in vivo molecular imaging

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Abstract

A facile method for the preparation of antibody–quantum dot (QD) conjugates using the immunoglobulin binding (B1) domain of protein G is presented. The utility of antibody–QD conjugates using the B1 domain is demonstrated for fluorescence imaging of breast tumor cells in vitro and in vivo.

Graphical abstract: Immunoglobulin binding (B1) domain mediated antibody conjugation to quantum dots for in vitro and in vivo molecular imaging

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Publication details

The article was received on 27 Jun 2017, accepted on 31 Jul 2017 and first published on 02 Aug 2017


Article type: Communication
DOI: 10.1039/C7CC04966H
Citation: Chem. Commun., 2017, Advance Article
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    Immunoglobulin binding (B1) domain mediated antibody conjugation to quantum dots for in vitro and in vivo molecular imaging

    S. Tsuboi, A. Sasaki, T. Sakata, H. Yasuda and T. Jin, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC04966H

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