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Oxidation-induced C-H amination leads new avenue to build C-N bonds

Abstract

In this work, we developed an oxidation-induced C-H functionalization strategy, which leads not only a new avenue to build C-N bonds, but also leads different site-selectivity compared with “classic-directing-groups”. Using readily available CuBr as the catalyst precursor and (NH4)2S2O8 as the oxidant, a series of aromatics and azoles could be coupled in selective-manner up to 92% yield. The high selectivity of our new catalytic system originated from the heterogeneous electron-density distribution of the radical cation species which were induced by single electron transfer between aromatics and oxidant-Cu(II) species.

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Publication details

The article was received on 27 Jun 2017, accepted on 13 Jul 2017 and first published on 13 Jul 2017


Article type: Communication
DOI: 10.1039/C7CC04955B
Citation: Chem. Commun., 2017, Accepted Manuscript
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    Oxidation-induced C-H amination leads new avenue to build C-N bonds

    H. Yi, Z. Tang, C. Bian, H. Chen, X. Qi, X. Yue, Y. Lan, J. Lee and A. Lei, Chem. Commun., 2017, Accepted Manuscript , DOI: 10.1039/C7CC04955B

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