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Issue 66, 2017
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A cascade enzymatic reaction activatable gemcitabine prodrug with an AIE-based intracellular light-up apoptotic probe for in situ self-therapeutic monitoring

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Abstract

A targeted cathepsin B-activatable gemcitabine prodrug with caspase-3 specific light-up tetraphenylene (TPE) as an apoptotic probe based on aggregation-induced emission (AIE) properties was designed for in situ self-therapeutic monitoring of pancreatic cancer cells.

Graphical abstract: A cascade enzymatic reaction activatable gemcitabine prodrug with an AIE-based intracellular light-up apoptotic probe for in situ self-therapeutic monitoring

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Publication details

The article was received on 23 Jun 2017, accepted on 25 Jul 2017 and first published on 25 Jul 2017


Article type: Communication
DOI: 10.1039/C7CC04872F
Citation: Chem. Commun., 2017,53, 9214-9217
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    A cascade enzymatic reaction activatable gemcitabine prodrug with an AIE-based intracellular light-up apoptotic probe for in situ self-therapeutic monitoring

    H. Han, W. Teng, T. Chen, J. Zhao, Q. Jin, Z. Qin and J. Ji, Chem. Commun., 2017, 53, 9214
    DOI: 10.1039/C7CC04872F

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