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Issue 68, 2017
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Nonconventional difluoroalkylation of C(sp2)–H bonds through hydroarylation

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Abstract

An unprecedented Rh-catalyzed C2-difluoroalkylation of indole derivatives with 2,2-difluorovinyl arenesulfonates has been reported. This reaction provides a rare instance of catalytic difluoroalkylation through hydroarylation of gem-difluoroalkenes. The sulfonate group works as a chelating ligand, thus stabilizing the rhodacycle intermediate, leading to the uncommon transformation.

Graphical abstract: Nonconventional difluoroalkylation of C(sp2)–H bonds through hydroarylation

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Publication details

The article was received on 22 Jun 2017, accepted on 31 Jul 2017 and first published on 01 Aug 2017


Article type: Communication
DOI: 10.1039/C7CC04842D
Citation: Chem. Commun., 2017,53, 9482-9485
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    Nonconventional difluoroalkylation of C(sp2)–H bonds through hydroarylation

    C. Zhu, S. Song, L. Zhou, D. Wang, C. Feng and T. Loh, Chem. Commun., 2017, 53, 9482
    DOI: 10.1039/C7CC04842D

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