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Issue 58, 2017
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Gold-loaded nanoporous superparamagnetic nanocubes for catalytic signal amplification in detecting miRNA

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Abstract

This paper reports the development of a nonenzymatic, amplification-free, and sensitive platform for the detection of microRNA based on a new class of electrocatalytically active superparamagnetic gold-loaded nanoporous iron oxide nanocubes (Au@NPFe2O3NC). The assay showed an excellent detection sensitivity down to 100 fM and specificity towards the analysis of miR-21 in cell lines and tissue samples derived from patients with oesophageal squamous-cell carcinoma (ESCC).

Graphical abstract: Gold-loaded nanoporous superparamagnetic nanocubes for catalytic signal amplification in detecting miRNA

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Publication details

The article was received on 20 Jun 2017, accepted on 30 Jun 2017 and first published on 30 Jun 2017


Article type: Communication
DOI: 10.1039/C7CC04789D
Citation: Chem. Commun., 2017,53, 8231-8234
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    Gold-loaded nanoporous superparamagnetic nanocubes for catalytic signal amplification in detecting miRNA

    M. Kamal Masud, Md. N. Islam, Md. H. Haque, S. Tanaka, V. Gopalan, G. Alici, N. Nguyen, A. K. Lam, Md. S. A. Hossain, Y. Yamauchi and M. J. A. Shiddiky, Chem. Commun., 2017, 53, 8231
    DOI: 10.1039/C7CC04789D

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