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In situ generation of electrochemiluminescent DNA nanoflowers as a signal tag for mucin 1 detection based on a strategy of target and mimic target synchronous cycling amplification

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Abstract

A sensitive electrochemiluminescent (ECL) aptasensor consisting of a novel ECL signal tag of DNA nanoflowers (DNA NFs) and a highly efficient target conversion strategy for the MUC1 assay was developed, which not only increased the stability for luminophore loading, but also greatly improved the detection sensitivity.

Graphical abstract: In situ generation of electrochemiluminescent DNA nanoflowers as a signal tag for mucin 1 detection based on a strategy of target and mimic target synchronous cycling amplification

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Publication details

The article was received on 19 Jun 2017, accepted on 04 Aug 2017 and first published on 08 Aug 2017


Article type: Communication
DOI: 10.1039/C7CC04747A
Citation: Chem. Commun., 2017, Advance Article
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    In situ generation of electrochemiluminescent DNA nanoflowers as a signal tag for mucin 1 detection based on a strategy of target and mimic target synchronous cycling amplification

    S. Li, A. Chen, X. Niu, Z. Liu, M. Du, Y. Chai, R. Yuan and Y. Zhuo, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC04747A

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