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Issue 67, 2017
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Copper-catalyzed silylation reactions of propargyl epoxides: easy access to 2,3-allenols and stereodefined alkenes

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Abstract

Efficient silylation reactions of propargyl epoxides catalyzed by copper catalysts have been developed. Under mild reaction conditions, tri- and tetra-substituted functionalized allenols and alkenes could be selectively obtained in moderate to high yields via tuning the bases and solvents used in the reactions. This work provides straightforward and efficient approaches to the synthesis of multifunctionalized 2,3-allenols and stereodefined alkenes from the same starting material of propargyl epoxides.

Graphical abstract: Copper-catalyzed silylation reactions of propargyl epoxides: easy access to 2,3-allenols and stereodefined alkenes

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Publication details

The article was received on 13 Jun 2017, accepted on 21 Jul 2017 and first published on 21 Jul 2017


Article type: Communication
DOI: 10.1039/C7CC04588C
Citation: Chem. Commun., 2017,53, 9344-9347
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    Copper-catalyzed silylation reactions of propargyl epoxides: easy access to 2,3-allenols and stereodefined alkenes

    X. Chang, Z. Liu, Y. Luo, C. Yang, X. Liu, B. Da, J. Li, T. Ahmad, T. Loh and Y. Xu, Chem. Commun., 2017, 53, 9344
    DOI: 10.1039/C7CC04588C

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