Jump to main content
Jump to site search


Rapid and ultrasensitive detection of endocrine disrupting chemicals using a nanosensor-enabled cell-based platform

Author affiliations

Abstract

Endocrine disrupting chemicals (EDCs) interact with estrogen receptors (ERs), causing a broad range of adverse health effects. Current assays for EDC activity are slow and often lack sensitivity. We report here an ultra-sensitive nanosensor that can detect estrogenic cellular changes in ER(+) MCF-7 cells rapidly (minutes) at several orders of magnitude lower than the generally used assays. Notably, the sensor responses at these ultra-low EDC levels correlated with an increased synthesis phase (S-phase) cell population of EDC-treated cells. The nanosensor was also able to detect binary EDC mixture effects, with synergism observed for bisphenol A (BPA) – 17β-estradiol (E2), and antagonism for dicyclohexylphthalate (DCHP) – E2 and benzo(a)pyrene (BaP) – E2.

Graphical abstract: Rapid and ultrasensitive detection of endocrine disrupting chemicals using a nanosensor-enabled cell-based platform

Back to tab navigation

Supplementary files

Publication details

The article was received on 12 Jun 2017, accepted on 12 Jul 2017 and first published on 13 Jul 2017


Article type: Communication
DOI: 10.1039/C7CC04561A
Citation: Chem. Commun., 2017, Advance Article
  •   Request permissions

    Rapid and ultrasensitive detection of endocrine disrupting chemicals using a nanosensor-enabled cell-based platform

    N. D. B. Le, X. Wang, Y. Geng, R. Tang, G. Y. Tonga, Z. Jiang and V. M. Rotello, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC04561A

Search articles by author

Spotlight

Advertisements