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Acyclic cucurbit[n]uril conjugated dextran for drug encapsulation and bioimaging

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Abstract

An acyclic cucurbit[n]uril (CB[n]) conjugated dextran is developed as a new biomaterial for drug delivery and bioimaging. This biomaterial retains the host–guest recognition properties of acyclic CB[n]s. It is able to directly encapsulate anti-tumor drugs 5-fluorouracil and temozolomide. This polymeric material can form a supramolecular assembly with polyethyleneimine (PEI). Although there is no conventional chromophore in these supramolecular systems, they exhibit aggregation-induced emission (AIE) in water with a quantum yield of 10%. This supramolecular assembly is used for bioimaging in vitro with good biocompatibility.

Graphical abstract: Acyclic cucurbit[n]uril conjugated dextran for drug encapsulation and bioimaging

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Publication details

The article was received on 12 Jun 2017, accepted on 11 Jul 2017 and first published on 11 Jul 2017


Article type: Communication
DOI: 10.1039/C7CC04535B
Citation: Chem. Commun., 2017, Advance Article
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    Acyclic cucurbit[n]uril conjugated dextran for drug encapsulation and bioimaging

    J. Chen, Y. Liu, D. Mao and D. Ma, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC04535B

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