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Supercharging SpyCatcher toward an intrinsically disordered protein with stimuli-responsive chemical reactivity

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Abstract

We report a supercharged, intrinsically disordered protein, SpyCatcher(−), possessing stimuli-responsive reactivity toward SpyTag with tunable yields ranging from 4% to 98% depending on pH, temperature, ionic strength, etc. The CD and NMR studies reveal that the reaction occurs through a folded intermediate formed probably via a different mechanism from that of SpyCatcher.

Graphical abstract: Supercharging SpyCatcher toward an intrinsically disordered protein with stimuli-responsive chemical reactivity

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Publication details

The article was received on 10 Jun 2017, accepted on 28 Jun 2017 and first published on 28 Jun 2017


Article type: Communication
DOI: 10.1039/C7CC04507G
Citation: Chem. Commun., 2017, Advance Article
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    Supercharging SpyCatcher toward an intrinsically disordered protein with stimuli-responsive chemical reactivity

    Y. Cao, D. Liu and W. Zhang, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC04507G

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