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H2-Driven biocatalytic hydrogenation in continuous flow using enzyme-modified carbon nanotube columns

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Abstract

We describe the implementation of a system of immobilised enzymes for H2-driven NADH recycling coupled to a selective biotransformation to enable H2-driven biocatalysis in flow. This approach represents a platform that can be optimised for a wide range of hydrogenation steps and is shown here for enantioselective ketone reduction and reductive amination.

Graphical abstract: H2-Driven biocatalytic hydrogenation in continuous flow using enzyme-modified carbon nanotube columns

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Publication details

The article was received on 08 Jun 2017, accepted on 02 Aug 2017 and first published on 04 Aug 2017


Article type: Communication
DOI: 10.1039/C7CC04465H
Citation: Chem. Commun., 2017, Advance Article
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    H2-Driven biocatalytic hydrogenation in continuous flow using enzyme-modified carbon nanotube columns

    C. Zor, H. A. Reeve, J. Quinson, L. A. Thompson, T. H. Lonsdale, F. Dillon, N. Grobert and K. A. Vincent, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC04465H

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