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Issue 61, 2017
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Formation of ionic co-crystals of amphoteric azoles directed by the ionic liquid co-former 1-ethyl-3-methylimidazolium acetate

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Abstract

The ionic liquid (IL) 1-ethyl-3-methylimidazolium acetate was utilized as a liquid-state crystallization agent to form ionic co-crystals using amphoteric azoles selected as model compounds for active pharmaceutical ingredients. Weakly acidic azoles crystallize the IL relatively quickly, while stronger acidic azoles undergo slower ion exchange with the IL to form salts.

Graphical abstract: Formation of ionic co-crystals of amphoteric azoles directed by the ionic liquid co-former 1-ethyl-3-methylimidazolium acetate

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Publication details

The article was received on 07 Jun 2017, accepted on 11 Jul 2017 and first published on 11 Jul 2017


Article type: Communication
DOI: 10.1039/C7CC04429A
Citation: Chem. Commun., 2017,53, 8569-8572
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    Formation of ionic co-crystals of amphoteric azoles directed by the ionic liquid co-former 1-ethyl-3-methylimidazolium acetate

    H. M. Titi, S. P. Kelley, M. E. Easton, S. D. Emerson and R. D. Rogers, Chem. Commun., 2017, 53, 8569
    DOI: 10.1039/C7CC04429A

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