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Radiofluorination of a NHC–PF5 adduct: toward new probes for 18F PET imaging

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Abstract

The radiofluorination of N-heterocyclic carbene (NHC) phosphorus(V) fluoride adducts has been investigated. The results show that the IMe-PF5 derivative (IMe = 1,3-dimethylimidazol-2-ylidene) undergoes a Lewis acid promoted 18F–19F isotopic exchange. The resulting radiofluorinated probe is remarkably resistant to hydrolysis both in vitro as well as in vivo.

Graphical abstract: Radiofluorination of a NHC–PF5 adduct: toward new probes for 18F PET imaging

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Publication details

The article was received on 07 Jun 2017, accepted on 11 Jul 2017 and first published on 11 Jul 2017


Article type: Communication
DOI: 10.1039/C7CC04402J
Citation: Chem. Commun., 2017, Advance Article
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    Radiofluorination of a NHC–PF5 adduct: toward new probes for 18F PET imaging

    B. Vabre, K. Chansaenpak, M. Wang, H. Wang, Z. Li and F. P. Gabbaï, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC04402J

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