Jump to main content
Jump to site search


Chemical proteomics reveal CD147 as a functional target of pseudolaric acid B in human cancer cells

Author affiliations

Abstract

CD147 is a glycosylated transmembrane protein highly expressed on the surface of various tumor cells which plays vital roles in tumor invasion, progression and metastasis. We report the discovery of the natural product pseudolaric acid B (PAB) directly targeting CD147 by chemical proteomics utilizing a PAB-derived photoaffinity probe which could serve as a novel type of anticancer reagent.

Graphical abstract: Chemical proteomics reveal CD147 as a functional target of pseudolaric acid B in human cancer cells

Back to tab navigation

Supplementary files

Publication details

The article was received on 05 Jun 2017, accepted on 10 Jul 2017 and first published on 10 Jul 2017


Article type: Communication
DOI: 10.1039/C7CC04345G
Citation: Chem. Commun., 2017, Advance Article
  •   Request permissions

    Chemical proteomics reveal CD147 as a functional target of pseudolaric acid B in human cancer cells

    Y. Zhou, Z. Di, X. Li, Y. Shan, W. Li, H. Zhang and Y. Xiao, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC04345G

Search articles by author

Spotlight

Advertisements