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Palladium-catalyzed aminocarbonylation of halo-substituted 7-azaindoles and other heteroarenes using chloroform as a carbon monoxide source

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Abstract

A palladium-catalyzed aminocarbonylation of halo-substituted 7-azaindoles utilizing CHCl3 as the carbonyl source has been developed for the straightforward incorporation of an amide functional group. The protocol was extended to other heteroarenes such as pyrazolopyridines and indazoles. The substrate scope of the reaction with respect to heteroarenes and the amine component is reported. This method offers an alternative avenue for aminocarbonylation of pharmaceutically important heterocycles.

Graphical abstract: Palladium-catalyzed aminocarbonylation of halo-substituted 7-azaindoles and other heteroarenes using chloroform as a carbon monoxide source

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Publication details

The article was received on 05 Jun 2017, accepted on 02 Aug 2017 and first published on 02 Aug 2017


Article type: Communication
DOI: 10.1039/C7CC04339B
Citation: Chem. Commun., 2017, Advance Article
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    Palladium-catalyzed aminocarbonylation of halo-substituted 7-azaindoles and other heteroarenes using chloroform as a carbon monoxide source

    P. Kannaboina, G. Raina, K. Anil Kumar and P. Das, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC04339B

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