Issue 60, 2017

l-Lysine based lipidated biphenyls as agents with anti-biofilm and anti-inflammatory properties that also inhibit intracellular bacteria

Abstract

L-Lysines were conjugated to lipidated biphenyls using simple synthetic chemistry to obtain selective membrane-active antibacterial agents that inhibit cell-wall biosynthesis. The most selective compound bore promising activity against biofilm-related infections and intracellular bacteria, and also suppressed the stimulation of TNF-α induced by lipoteichoic acid. Belligerent to resistance development, it was active in a murine model of MRSA infection.

Graphical abstract: l-Lysine based lipidated biphenyls as agents with anti-biofilm and anti-inflammatory properties that also inhibit intracellular bacteria

Supplementary files

Article information

Article type
Communication
Submitted
08 Jun 2017
Accepted
30 Jun 2017
First published
30 Jun 2017

Chem. Commun., 2017,53, 8427-8430

L-Lysine based lipidated biphenyls as agents with anti-biofilm and anti-inflammatory properties that also inhibit intracellular bacteria

C. Ghosh, P. Sarkar, S. Samaddar, D. S. S. M. Uppu and J. Haldar, Chem. Commun., 2017, 53, 8427 DOI: 10.1039/C7CC04206J

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