Jump to main content
Jump to site search

Issue 60, 2017
Previous Article Next Article

L-Lysine based lipidated biphenyls as agents with anti-biofilm and anti-inflammatory properties that also inhibit intracellular bacteria

Author affiliations

Abstract

L-Lysines were conjugated to lipidated biphenyls using simple synthetic chemistry to obtain selective membrane-active antibacterial agents that inhibit cell-wall biosynthesis. The most selective compound bore promising activity against biofilm-related infections and intracellular bacteria, and also suppressed the stimulation of TNF-α induced by lipoteichoic acid. Belligerent to resistance development, it was active in a murine model of MRSA infection.

Graphical abstract: l-Lysine based lipidated biphenyls as agents with anti-biofilm and anti-inflammatory properties that also inhibit intracellular bacteria

Back to tab navigation

Supplementary files

Publication details

The article was received on 08 Jun 2017, accepted on 30 Jun 2017 and first published on 30 Jun 2017


Article type: Communication
DOI: 10.1039/C7CC04206J
Citation: Chem. Commun., 2017,53, 8427-8430
  •   Request permissions

    L-Lysine based lipidated biphenyls as agents with anti-biofilm and anti-inflammatory properties that also inhibit intracellular bacteria

    C. Ghosh, P. Sarkar, S. Samaddar, D. S. S. M. Uppu and J. Haldar, Chem. Commun., 2017, 53, 8427
    DOI: 10.1039/C7CC04206J

Search articles by author

Spotlight

Advertisements