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Issue 53, 2017
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Incorporation of native antibodies and Fc-fusion proteins on DNA nanostructures via a modular conjugation strategy

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Abstract

A photocrosslinkable protein G variant was used as an adapter protein to covalently and site-specifically conjugate an antibody and an Fc-fusion protein to an oligonucleotide. This modular approach enables straightforward decoration of DNA nanostructures with complex native proteins while retaining their innate binding affinity, allowing precise control over the nanoscale spatial organization of such proteins for in vitro and in vivo biomedical applications.

Graphical abstract: Incorporation of native antibodies and Fc-fusion proteins on DNA nanostructures via a modular conjugation strategy

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Publication details

The article was received on 30 May 2017, accepted on 09 Jun 2017 and first published on 09 Jun 2017


Article type: Communication
DOI: 10.1039/C7CC04178K
Citation: Chem. Commun., 2017,53, 7393-7396
  • Open access: Creative Commons BY license
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    Incorporation of native antibodies and Fc-fusion proteins on DNA nanostructures via a modular conjugation strategy

    B. J. H. M. Rosier, G. A. O. Cremers, W. Engelen, M. Merkx, L. Brunsveld and T. F. A. de Greef, Chem. Commun., 2017, 53, 7393
    DOI: 10.1039/C7CC04178K

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