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Issue 62, 2017
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Manganese-catalyzed synthesis of monofluoroalkenes via C–H activation and C–F cleavage

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Abstract

The manganese-catalyzed α-fluoroalkenylation of arenes via C–H activation and C–F cleavage has been described. This protocol provides a very useful method for the synthesis of monofluoroalkenes with predominant unconventional E-isomer selectivity which complements the existing strategies for the access to these molecular architectures. In addition, the selectivity of β-defluorination in the catalytic cycle not only determines the configurations of the products but also obviates the use of external oxidants, providing a good example in the exploitation of manganese-catalyzed redox-neutral C–H transformations.

Graphical abstract: Manganese-catalyzed synthesis of monofluoroalkenes via C–H activation and C–F cleavage

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Publication details

The article was received on 29 May 2017, accepted on 10 Jul 2017 and first published on 10 Jul 2017


Article type: Communication
DOI: 10.1039/C7CC04131D
Citation: Chem. Commun., 2017,53, 8731-8734
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    Manganese-catalyzed synthesis of monofluoroalkenes via C–H activation and C–F cleavage

    S. Cai, L. Ye, D. Wang, Y. Wang, L. Lai, C. Zhu, C. Feng and T. Loh, Chem. Commun., 2017, 53, 8731
    DOI: 10.1039/C7CC04131D

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