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Rational Synthesis of Hierarchical Magnetic Mesoporous Silica Microspheres with Tunable Mesochannels for Enhanced Enzymes Immobilization

Abstract

The pore size of mesoporous materials affects the enzyme immobilization efficiency for biocatalysis. In this study, hierarchical magnetic mesoporous silica microspheres (MMSM) in core-shell structure have been fabricated through an improved water/oil biphase synthesis strategy, which possess larger pore size of 11.4 nm. We revealed the mesopore size can be readily tuned from 6.1 to 11.4 nm by the synergistic effect of surfactant concentration and amphiphilic agent. A facile and green method was also developed to meticulous functionalize the inner walls of mesopores with hydrophilic dopamine via slowly self-polymerization, avoiding the blocking off mesopores. The as-synthesized hybrid multifunctional MMSM possess strong magnetic responsitivity, high loading capacity, and excellent biocompatibility with less influence on the activities of enzymes, thus hold a bright future in many other possibly applications.

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Publication details

The article was received on 27 May 2017, accepted on 13 Jul 2017 and first published on 13 Jul 2017


Article type: Communication
DOI: 10.1039/C7CC04070A
Citation: Chem. Commun., 2017, Accepted Manuscript
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    Rational Synthesis of Hierarchical Magnetic Mesoporous Silica Microspheres with Tunable Mesochannels for Enhanced Enzymes Immobilization

    D. Li, R. Yi, J. Tian, J. Li, B. Yu and J. Qi, Chem. Commun., 2017, Accepted Manuscript , DOI: 10.1039/C7CC04070A

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