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pH-responsive de-PEGylated nanoparticles based on triphenylphosphine-quercetin self-assemblies for mitochondria-targeted cancer therapy

Abstract

We have developed mitochondria-targeted self-assembled nanoparticles (NPs) based on amphiphilic triphenylphosphine-quercetin conjugates (TPP-Que), which was further modified by poly(ethylene glycol) via pH-responsive coordination bond to form TQ-PEG NPs. And it is revealed that that the TQ-PEG NPs were more effective therapeutic agent compared with Que in vitro and in vivo.

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Publication details

The article was received on 31 May 2017, accepted on 14 Jul 2017 and first published on 14 Jul 2017


Article type: Communication
DOI: 10.1039/C7CC04058J
Citation: Chem. Commun., 2017, Accepted Manuscript
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    pH-responsive de-PEGylated nanoparticles based on triphenylphosphine-quercetin self-assemblies for mitochondria-targeted cancer therapy

    H. Jiang, L. Xing, J. Lyu, Y. Yang, P. Cui, L. Gu, J. Qiao, Y. He, T. Zhang, M. Sun, J. Lu, X. Xu and Y. Liu, Chem. Commun., 2017, Accepted Manuscript , DOI: 10.1039/C7CC04058J

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