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pH-Responsive de-PEGylated nanoparticles based on triphenylphosphine–quercetin self-assemblies for mitochondria-targeted cancer therapy

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Abstract

We have developed mitochondria-targeted self-assembled nanoparticles (NPs) based on amphiphilic triphenylphosphine–quercetin (TPP–Que) conjugates, which were further modified by poly(ethylene glycol) via a pH-responsive coordination bond to form TQ-PEG NPs. And it is revealed that the TQ-PEG NPs were more effective therapeutic agents compared with Que in vitro and in vivo.

Graphical abstract: pH-Responsive de-PEGylated nanoparticles based on triphenylphosphine–quercetin self-assemblies for mitochondria-targeted cancer therapy

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Publication details

The article was received on 31 May 2017, accepted on 14 Jul 2017 and first published on 14 Jul 2017


Article type: Communication
DOI: 10.1039/C7CC04058J
Citation: Chem. Commun., 2017, Advance Article
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    pH-Responsive de-PEGylated nanoparticles based on triphenylphosphine–quercetin self-assemblies for mitochondria-targeted cancer therapy

    L. Xing, J. Lyu, Y. Yang, P. Cui, L. Gu, J. Qiao, Y. He, T. Zhang, M. Sun, J. Lu, X. Xu, Y. Liu and H. Jiang, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC04058J

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