Issue 62, 2017
From the journal:

Chemical Communications

pH-Responsive de-PEGylated nanoparticles based on triphenylphosphine–quercetin self-assemblies for mitochondria-targeted cancer therapy†

Lei Xing,‡abc   Jin-Yuan Lyu,‡a   Yue Yang,‡d   Peng-Fei Cui,a   Liu-Qing Gu,a   Jian-Bin Qiao,a   Yu-Jing He,a   Tian-Qi Zhang,a   Minjie Sun,a   Jin-Jian Lu, ORCID logo e   Xiaojun Xu,*a   Yu Liu*d  and  Hu-Lin Jiang ORCID logo *abc  

* Corresponding authors

a State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China
E-mail: jianghulin3@163.com, xiaojunxu2000@163.com
Fax: +86-25-83271027
Tel: +86-25-83271027

b Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, China Pharmaceutical University, Nanjing, China

c Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, China

d Department of Biochemistry, School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China
E-mail: liuyuyaoda@163.com
Fax: +86-25-83271019
Tel: +86-25-83271543

e State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China

Abstract

We have developed mitochondria-targeted self-assembled nanoparticles (NPs) based on amphiphilic triphenylphosphine–quercetin (TPP–Que) conjugates, which were further modified by poly(ethylene glycol) via a pH-responsive coordination bond to form TQ-PEG NPs. And it is revealed that the TQ-PEG NPs were more effective therapeutic agents compared with Que in vitro and in vivo.

Graphical abstract: pH-Responsive de-PEGylated nanoparticles based on triphenylphosphine–quercetin self-assemblies for mitochondria-targeted cancer therapy

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Article information

DOI
https://doi.org/10.1039/C7CC04058J
Article type
Communication
Submitted
31 May 2017
Accepted
14 Jul 2017
First published
14 Jul 2017

Chem. Commun., 2017,53, 8790-8793

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pH-Responsive de-PEGylated nanoparticles based on triphenylphosphine–quercetin self-assemblies for mitochondria-targeted cancer therapy

L. Xing, J. Lyu, Y. Yang, P. Cui, L. Gu, J. Qiao, Y. He, T. Zhang, M. Sun, J. Lu, X. Xu, Y. Liu and H. Jiang, Chem. Commun., 2017, 53, 8790 DOI: 10.1039/C7CC04058J

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