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Issue 58, 2017
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A bioconjugate leveraging xenoreactive antibodies to alleviate cocaine-induced behavior

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Abstract

A method for potentiating the response to an anti-cocaine vaccine by leveraging xenoreactive antibodies against the carbohydrate epitope Galα1,3-Gal (GAL) was found to result in a highly specific anti-cocaine response that was able to significantly attenuate cocaine-induced locomotion at 20 mg kg−1 with superior efficacy compared to a standard conjugate.

Graphical abstract: A bioconjugate leveraging xenoreactive antibodies to alleviate cocaine-induced behavior

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Publication details

The article was received on 25 May 2017, accepted on 24 Jun 2017 and first published on 27 Jun 2017


Article type: Communication
DOI: 10.1039/C7CC04055E
Citation: Chem. Commun., 2017,53, 8156-8159
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    A bioconjugate leveraging xenoreactive antibodies to alleviate cocaine-induced behavior

    N. T. Jacob, K. Anraku, A. Kimishima, B. Zhou, K. C. Collins, J. W. Lockner, B. A. Ellis and K. D. Janda, Chem. Commun., 2017, 53, 8156
    DOI: 10.1039/C7CC04055E

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