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Issue 66, 2017
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Highly efficient synthesis of chiral aromatic ketones via Rh-catalyzed asymmetric hydrogenation of β,β-disubstituted enones

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Abstract

A succinct and efficient protocol was developed for the synthesis of chiral aromatic ketones via asymmetric hydrogenation of β,β-disubstituted enones with rhodium catalysts based on chiral bisphosphine thiourea ligands. A series of substrates (17 examples) was smoothly catalyzed to afford the corresponding chiral aromatic ketones in high conversions (>99%) with excellent enantioselectivities (up to 96% ee).

Graphical abstract: Highly efficient synthesis of chiral aromatic ketones via Rh-catalyzed asymmetric hydrogenation of β,β-disubstituted enones

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Publication details

The article was received on 25 May 2017, accepted on 20 Jul 2017 and first published on 21 Jul 2017


Article type: Communication
DOI: 10.1039/C7CC04045H
Citation: Chem. Commun., 2017,53, 9258-9261
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    Highly efficient synthesis of chiral aromatic ketones via Rh-catalyzed asymmetric hydrogenation of β,β-disubstituted enones

    T. Zhang, J. Jiang, L. Yao, H. Geng and X. Zhang, Chem. Commun., 2017, 53, 9258
    DOI: 10.1039/C7CC04045H

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