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Biomimetic iterative method for polyketide synthesis

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Abstract

An iterative method for synthesizing polyketides was demonstrated, in which the chain elongation of a carboxylic acid was performed by decarboxylative dehydration condensation with a malonic acid half thioester. After transforming the resulting β-ketothioester into an appropriate form, the carboxylic acid functionality was regenerated for the next elongation step.

Graphical abstract: Biomimetic iterative method for polyketide synthesis

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Publication details

The article was received on 25 May 2017, accepted on 08 Jun 2017 and first published on 08 Jun 2017


Article type: Communication
DOI: 10.1039/C7CC04033D
Citation: Chem. Commun., 2017, Advance Article
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    Biomimetic iterative method for polyketide synthesis

    K. Akagawa and K. Kudo, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC04033D

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