Issue 54, 2017

An enantioselective cascade for simultaneous generation of five quaternary stereocenters from fully substituted enones

Abstract

A highly enantioselective cascade reaction for the generation of five quaternary stereocenters in one-pot operation is reported for the first time in the history of organic synthesis. Cinchona-alkaloid derived hydrogen-bonding catalyst furnished structurally complex cascade products from simple substrates in excellent yields and stereoselectivities.

Graphical abstract: An enantioselective cascade for simultaneous generation of five quaternary stereocenters from fully substituted enones

Supplementary files

Article information

Article type
Communication
Submitted
24 May 2017
Accepted
15 Jun 2017
First published
15 Jun 2017

Chem. Commun., 2017,53, 7649-7652

An enantioselective cascade for simultaneous generation of five quaternary stereocenters from fully substituted enones

S. Yang, G. M. Reddy, T. Wang, Y. Yeh, M. Wang and W. Lin, Chem. Commun., 2017, 53, 7649 DOI: 10.1039/C7CC03995F

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