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Issue 59, 2017
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Allosteric control of nanomechanical DNA origami pinching devices for enhanced target binding

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Abstract

Significant enhancement of single-molecular binding to a miRNA target and bidentate and asymmetric conjugation of two distinct thiolated DNA strands to single gold nanoparticles (AuNPs) were visibly demonstrated, by introducing two groups of ligands into our nanomechanical DNA origami devices (DNA pliers) to construct allosterically controllable systems.

Graphical abstract: Allosteric control of nanomechanical DNA origami pinching devices for enhanced target binding

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Publication details

The article was received on 23 May 2017, accepted on 26 Jun 2017 and first published on 27 Jun 2017


Article type: Communication
DOI: 10.1039/C7CC03991C
Citation: Chem. Commun., 2017,53, 8276-8279
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    Allosteric control of nanomechanical DNA origami pinching devices for enhanced target binding

    A. Kuzuya, Y. Sakai, T. Yamazaki, Y. Xu, Y. Yamanaka, Y. Ohya and M. Komiyama, Chem. Commun., 2017, 53, 8276
    DOI: 10.1039/C7CC03991C

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