Thiol-reactive (co)polymer scaffolds comprising organic arsenical acrylamides

Abstract

Novel, well-defined organic arsenical homopolymers (Đ = 1.10–1.40) have been synthesised via RAFT polymerisation. Copolymerisation of the As-functional monomer with dimethylacrylamide yielded non-toxic polymer scaffolds (Đ ≈ 1.10) that could be manipulated in response to pH and undergo sequential reduction and substitution in the presence of thiols including cysteine and glutathione.