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Issue 59, 2017
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An esterase-activated click and release approach to metal-free CO-prodrugs

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Abstract

One major challenge in the development of CO as a therapeutic agent is its controllable delivery in a pharmaceutically acceptable form. Herein, we describe for the first time a general chemical strategy to esterase-sensitive organic CO-prodrugs.

Graphical abstract: An esterase-activated click and release approach to metal-free CO-prodrugs

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Publication details

The article was received on 18 May 2017, accepted on 29 Jun 2017 and first published on 29 Jun 2017


Article type: Communication
DOI: 10.1039/C7CC03832A
Citation: Chem. Commun., 2017,53, 8296-8299
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    An esterase-activated click and release approach to metal-free CO-prodrugs

    X. Ji, K. Ji, V. Chittavong, B. Yu, Z. Pan and B. Wang, Chem. Commun., 2017, 53, 8296
    DOI: 10.1039/C7CC03832A

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