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Issue 48, 2017
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A fluorescence turn-on probe for human (bovine) serum albumin based on the hydrolysis of a dioxaborine group promoted by proteins

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Abstract

A fluorescence “off–on” probe CBF, constructed by incorporating a dioxaborine unit into a microenvironment-sensitive fluorophore, was developed for serum albumin (SA). Upon binding to SA, the dioxaborine group in CBF was hydrolyzed into β-diketonate, which triggered dramatic fluorescence enhancement (over 1000-fold) along with a remarkable blue-shift (∼100 nm). The bioimaging results suggested that more SA were taken in by cancer cells.

Graphical abstract: A fluorescence turn-on probe for human (bovine) serum albumin based on the hydrolysis of a dioxaborine group promoted by proteins

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Publication details

The article was received on 09 May 2017, accepted on 16 May 2017 and first published on 19 May 2017


Article type: Communication
DOI: 10.1039/C7CC03587J
Citation: Chem. Commun., 2017,53, 6432-6435
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    A fluorescence turn-on probe for human (bovine) serum albumin based on the hydrolysis of a dioxaborine group promoted by proteins

    Q. Sun, W. Wang, Z. Chen, Y. Yao, W. Zhang, L. Duan and J. Qian, Chem. Commun., 2017, 53, 6432
    DOI: 10.1039/C7CC03587J

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