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Evaluation of DFO-HOPO as an octadentate chelator for zirconium-89

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Abstract

The future of 89Zr-based immuno-PET is reliant upon the development of new chelators with improved stability compared to the currently used deferoxamine (DFO). Herein, we report the evaluation of the octadentate molecule DFO-HOPO (3) as a suitable chelator for 89Zr and a more stable alternative to DFO. The molecule showed good potential for the future development of a DFO-HOPO-based bifunctional chelator (BFC) for the radiolabelling of biomolecules with 89Zr. This work broadens the selection of available chelators for 89Zr in search of improved successors to DFO for clinical 89Zr-immuno-PET.

Graphical abstract: Evaluation of DFO-HOPO as an octadentate chelator for zirconium-89

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Publication details

The article was received on 08 May 2017, accepted on 07 Jul 2017 and first published on 12 Jul 2017


Article type: Communication
DOI: 10.1039/C7CC03572A
Citation: Chem. Commun., 2017, Advance Article
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    Evaluation of DFO-HOPO as an octadentate chelator for zirconium-89

    L. Allott, C. Da Pieve, J. Meyers, T. Spinks, D. M. Ciobota, G. Kramer-Marek and G. Smith, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC03572A

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