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Issue 54, 2017
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Nucleopolypeptides with DNA-triggered α helix-to-β sheet transition

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Abstract

Synthetic polypeptides are versatile polymers outstandingly relevant to prepare bioinspired materials. In this work, we present a new class of smart polypeptide polymers, called nucleopolypeptides, having lateral chains functionalized with thymidine nucleobases. Structural studies performed by circular dichroism have revealed that the secondary structure of the polymers was influenced by nucleotide interaction and DNA sequence variation affording a selective helix-to-beta sheet transition with oligo(AAAAA)6.

Graphical abstract: Nucleopolypeptides with DNA-triggered α helix-to-β sheet transition

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Publication details

The article was received on 04 May 2017, accepted on 07 Jun 2017 and first published on 07 Jun 2017


Article type: Communication
DOI: 10.1039/C7CC03472E
Citation: Chem. Commun., 2017,53, 7501-7504
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    Nucleopolypeptides with DNA-triggered α helix-to-β sheet transition

    M. Nguyen, J. Stigliani, G. Pratviel and C. Bonduelle, Chem. Commun., 2017, 53, 7501
    DOI: 10.1039/C7CC03472E

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