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Issue 54, 2017
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Direct N-acylation of sulfoximines with carboxylic acids catalyzed by the B3NO2 heterocycle

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Abstract

In contrast to recent significant progress in the development of catalytic methodologies for nitrogen acylations, syntheses of N-acyl sulfoximines have been slow to evolve, and still largely rely on the use of stoichiometric amounts of activating reagents. Here we describe the direct acylation of the nitrogen atom in sulfoximines with carboxylic acids promoted by a heterocyclic catalyst featuring the B3NO2 ring system. The protocol used was found to be operationally simple and to tolerate a wide range of functional groups, furnishing the N-acylated sulfoximines in good yield. The multiboron catalyst tamed previously intractable nitrogen nucleophiles, allowing for the short synthesis of a factor Xa inhibitor by catalyzing two consecutive nitrogen acylations in the same pot.

Graphical abstract: Direct N-acylation of sulfoximines with carboxylic acids catalyzed by the B3NO2 heterocycle

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Publication details

The article was received on 02 May 2017, accepted on 25 May 2017 and first published on 25 May 2017


Article type: Communication
DOI: 10.1039/C7CC03386A
Citation: Chem. Commun., 2017,53, 7447-7450
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    Direct N-acylation of sulfoximines with carboxylic acids catalyzed by the B3NO2 heterocycle

    H. Noda, Y. Asada, M. Shibasaki and N. Kumagai, Chem. Commun., 2017, 53, 7447
    DOI: 10.1039/C7CC03386A

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