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A targeted delivery strategy for the development of potent trypanocides

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Abstract

A new drug delivery strategy was investigated for the development of potent anti-parasitic compounds against Trypanosoma brucei, the causative agent of African sleeping sickness. Thus, potent in vitro hexokinase inhibitors were rendered cytotoxic by appending a tripeptide peroxosomal targeting sequence that facilitated delivery of the molecular cargo to the appropriate organelle in the parasite.

Graphical abstract: A targeted delivery strategy for the development of potent trypanocides

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Publication details

The article was received on 01 May 2017, accepted on 14 Jul 2017 and first published on 14 Jul 2017


Article type: Communication
DOI: 10.1039/C7CC03378H
Citation: Chem. Commun., 2017, Advance Article
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    A targeted delivery strategy for the development of potent trypanocides

    H. M. Gordhan, J. E. Milanes, Y. Qiu, J. E. Golden, K. A. Christensen, J. C. Morris and D. C. Whitehead, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC03378H

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