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Nickel-catalyzed ring-opening of α-hydroxycyclobutenones with a remarkable ligand effect

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Abstract

A Ni-catalyzed ring-opening of α-hydroxycyclobutenones is reported herein. A remarkable ligand effect was observed during transformations following the ring-opening. The employment of PPh3 leads to the formation of 2-furanones 2 through a migration of an alkoxyl group, and 2-furanones 3 were generated through a migration of hydrogen in the presence of Xantphos, affording a divergent approach to 2-furanones bearing multiple functional groups.

Graphical abstract: Nickel-catalyzed ring-opening of α-hydroxycyclobutenones with a remarkable ligand effect

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Publication details

The article was received on 29 Apr 2017, accepted on 04 Sep 2017 and first published on 04 Sep 2017


Article type: Communication
DOI: 10.1039/C7CC03340K
Citation: Chem. Commun., 2017, Advance Article
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    Nickel-catalyzed ring-opening of α-hydroxycyclobutenones with a remarkable ligand effect

    S. Gao and X. Hu, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC03340K

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