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Issue 58, 2017
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New pH-responsive gemini lipid derived co-liposomes for efficacious doxorubicin delivery to drug resistant cancer cells

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Abstract

A gemini version of the amphiphile palmitoyl homocysteine was synthesized. Co-liposomes were prepared using the gemini along with a natural zwitterionic lipid, DOPE and cholesterol at specified ratios. This afforded pH-responsive co-liposomes which could efficiently transport the anticancer drug, doxorubicin (DOX), across the DOX-resistant HeLa cancer cells in response to low pH of cellular endosomes.

Graphical abstract: New pH-responsive gemini lipid derived co-liposomes for efficacious doxorubicin delivery to drug resistant cancer cells

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Publication details

The article was received on 28 Apr 2017, accepted on 17 Jun 2017 and first published on 26 Jun 2017


Article type: Communication
DOI: 10.1039/C7CC03320F
Citation: Chem. Commun., 2017,53, 8184-8187
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    New pH-responsive gemini lipid derived co-liposomes for efficacious doxorubicin delivery to drug resistant cancer cells

    P. Moitra, K. Kumar, S. Sarkar, P. Kondaiah, W. Duan and S. Bhattacharya, Chem. Commun., 2017, 53, 8184
    DOI: 10.1039/C7CC03320F

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