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Development of an RNA aptamer that acquires binding capacity against HIV-1 Tat protein via G-quadruplex formation in response to potassium ions

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Abstract

For the development of K+-responsive RNA aptamers, we proposed a new general strategy that makes use of a G-quadruplex formation in response to K+. This is the first report of developing an RNA aptamer that demonstrates ON/OFF switching of its target-binding activity by sensing the addition/removal of K+.

Graphical abstract: Development of an RNA aptamer that acquires binding capacity against HIV-1 Tat protein via G-quadruplex formation in response to potassium ions

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Publication details

The article was received on 28 Apr 2017, accepted on 06 Jun 2017 and first published on 07 Jun 2017


Article type: Communication
DOI: 10.1039/C7CC03312E
Citation: Chem. Commun., 2017, Advance Article
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    Development of an RNA aptamer that acquires binding capacity against HIV-1 Tat protein via G-quadruplex formation in response to potassium ions

    Y. Yamaoki, T. Nagata, T. Mashima and M. Katahira, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC03312E

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