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Issue 54, 2017
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Base-catalyzed cascade synthesis of 2,3-dihydrofuro[2,3-b]pyridines and 2,3-dihydro-1H-pyrrolo[2,3-b]pyridines from N-propargylic β-enaminones

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Abstract

A novel protocol to prepare multi-substituted dihydrofuropyridine and dihydropyrrolopyridine derivatives from KOH-catalyzed reactions between readily available N-propargylic β-enaminones and arylaldehydes or N-sulfonyl imines has been developed in moderate to good yields.

Graphical abstract: Base-catalyzed cascade synthesis of 2,3-dihydrofuro[2,3-b]pyridines and 2,3-dihydro-1H-pyrrolo[2,3-b]pyridines from N-propargylic β-enaminones

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Publication details

The article was received on 28 Apr 2017, accepted on 12 Jun 2017 and first published on 12 Jun 2017


Article type: Communication
DOI: 10.1039/C7CC03308G
Citation: Chem. Commun., 2017,53, 7497-7500
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    Base-catalyzed cascade synthesis of 2,3-dihydrofuro[2,3-b]pyridines and 2,3-dihydro-1H-pyrrolo[2,3-b]pyridines from N-propargylic β-enaminones

    X. Yang, F. Hu, Y. Wang, C. Yang, X. Zou, J. Liu and Q. Zhang, Chem. Commun., 2017, 53, 7497
    DOI: 10.1039/C7CC03308G

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