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Issue 50, 2017
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Direct catalytic enantioselective Mannich-type reaction of α,α-dithioacetonitriles with imines using chiral bis(imidazoline)–Pd complexes

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Abstract

The first highly enantioselective reaction of α,α-dithioacetonitriles with imines has been developed. Good yields and enantioselectivity were observed for the reaction of various imines using chiral bis(imidazoline) catalysts. The obtained products can be converted into β-aminonitrile or 1,3-diaminoketone.

Graphical abstract: Direct catalytic enantioselective Mannich-type reaction of α,α-dithioacetonitriles with imines using chiral bis(imidazoline)–Pd complexes

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Publication details

The article was received on 28 Apr 2017, accepted on 01 Jun 2017 and first published on 01 Jun 2017


Article type: Communication
DOI: 10.1039/C7CC03307A
Citation: Chem. Commun., 2017,53, 6776-6779
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    Direct catalytic enantioselective Mannich-type reaction of α,α-dithioacetonitriles with imines using chiral bis(imidazoline)–Pd complexes

    M. Kondo, H. Saito and S. Nakamura, Chem. Commun., 2017, 53, 6776
    DOI: 10.1039/C7CC03307A

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