Issue 56, 2017

Genetic and chemical characterisation of the cornexistin pathway provides further insight into maleidride biosynthesis

Abstract

The biosynthesis of the herbicide cornexistin in the fungus Paecilomyces variotii was investigated by full sequencing of its genome, knockout of key genes within its biosynthetic gene cluster and isolation and identification of intermediate compounds. The general biosynthetic pathway resembles that of byssochlamic acid and other nonadrides in the early stages, but differs in requiring fewer enzymes in the key nonadride dimerisation step, and in the removal of one maleic anhydride moiety.

Graphical abstract: Genetic and chemical characterisation of the cornexistin pathway provides further insight into maleidride biosynthesis

Supplementary files

Article information

Article type
Communication
Submitted
28 Apr 2017
Accepted
23 Jun 2017
First published
23 Jun 2017

Chem. Commun., 2017,53, 7965-7968

Genetic and chemical characterisation of the cornexistin pathway provides further insight into maleidride biosynthesis

K. Williams, A. J. Szwalbe, C. Dickson, T. R. Desson, N. P. Mulholland, J. L. Vincent, J. M. Clough, A. M. Bailey, C. P. Butts, C. L. Willis, T. J. Simpson and R. J. Cox, Chem. Commun., 2017, 53, 7965 DOI: 10.1039/C7CC03303F

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