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A label-free ratiometric electrochemical DNA sensor for monitoring intracellular redox homeostasis

Abstract

Imbalance of intracellular redox homeostasis can affect DNA and RNA synthesis, signal transduction, enzyme activation and even the cell proliferation, and may cause severe diseases, such as cancer and Parkinson’s disease. Glutathione (GSH) is regarded as the key molecule to maintain the intracellular redox homeostasis. Measurement of GSH concentration has been used for evaluating the intracellular redox state. In this report, we constructed a label-free ratiometric signal-on electrochemical DNA sensor for monitoring intracellular GSH by DNA metallization-mediated hybridization chain reaction (HCR) amplification. Furthermore, the amplified ratiometric biosensor can discriminate cancer and normal cells due to their different GSH level.

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Publication details

The article was accepted on 16 May 2017 and first published on 16 May 2017


Article type: Communication
DOI: 10.1039/C7CC03239K
Citation: Chem. Commun., 2017, Accepted Manuscript
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    A label-free ratiometric electrochemical DNA sensor for monitoring intracellular redox homeostasis

    X. Liu, Z. Yan, Y. Sun, J. Ren and X. Qu, Chem. Commun., 2017, Accepted Manuscript , DOI: 10.1039/C7CC03239K

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