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Issue 59, 2017
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Ionic liquids with thioether motifs as synthetic cationic lipids for gene delivery

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Abstract

This study introduces a novel class of imidazolium- and ammonium-based ionic liquids possessing two C12 and C14 tails and thioether linkers designed for lipoplex-mediated DNA delivery. Imidazolium-based ionic liquids displayed efficient gene delivery properties with low toxicity. Thiol–yne click chemistry was employed for the facile and robust synthesis of these thioether-based cationic lipioids with enhanced lipophilicity and low fluidity.

Graphical abstract: Ionic liquids with thioether motifs as synthetic cationic lipids for gene delivery

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Publication details

The article was received on 26 Apr 2017, accepted on 04 Jul 2017 and first published on 04 Jul 2017


Article type: Communication
DOI: 10.1039/C7CC03235H
Citation: Chem. Commun., 2017,53, 8328-8331
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    Ionic liquids with thioether motifs as synthetic cationic lipids for gene delivery

    J. C. Gaitor, L. M. Paul, M. M. Reardon, T. Hmissa, S. Minkowicz, M. Regner, Y. Sheng, S. F. Michael, S. Isern and A. Mirjafari, Chem. Commun., 2017, 53, 8328
    DOI: 10.1039/C7CC03235H

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