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Chemoenzymatic synthesis of polypeptides containing the unnatural amino acid 2-aminoisobutyric acid

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Abstract

Polypeptides containing 2-aminoisobutyric acid (Aib) units as an unnatural amino acid residue were synthesized by papain-catalyzed chemoenzymatic polymerization of a tripeptide ethyl ester L-Ala-Aib-L-Ala-OEt in an aqueous medium. The Aib-containing polypeptide adopted an α-helix conformation in both the solid and solution phases, which was induced by the periodic Aib residue.

Graphical abstract: Chemoenzymatic synthesis of polypeptides containing the unnatural amino acid 2-aminoisobutyric acid

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Publication details

The article was received on 22 Apr 2017, accepted on 03 May 2017 and first published on 05 May 2017


Article type: Communication
DOI: 10.1039/C7CC03095A
Citation: Chem. Commun., 2017, Advance Article
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    Chemoenzymatic synthesis of polypeptides containing the unnatural amino acid 2-aminoisobutyric acid

    K. Tsuchiya and K. Numata, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC03095A

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