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Cp*CoIII-catalyzed directed C–H trifluoromethylthiolation of 2-phenylpyridines and 6-arylpurines

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Abstract

Cp*CoIII-catalyzed directed C–H trifluoromethylthiolation using N-trifluoromethylthiodibenzenesulfonimide as an electrophilic SCF3 source is described. 6-Arylpurines, an important structural motif in medicinal chemistry, and 2-phenylpyridines selectively afforded mono-trifluoromethylthiolated products in moderate to good yields using an inexpensive first-row transition metal catalyst.

Graphical abstract: Cp*CoIII-catalyzed directed C–H trifluoromethylthiolation of 2-phenylpyridines and 6-arylpurines

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Publication details

The article was received on 07 Feb 2017, accepted on 08 May 2017 and first published on 08 May 2017


Article type: Communication
DOI: 10.1039/C7CC03072J
Citation: Chem. Commun., 2017, Advance Article
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    Cp*CoIII-catalyzed directed C–H trifluoromethylthiolation of 2-phenylpyridines and 6-arylpurines

    M. Yoshida, K. Kawai, R. Tanaka, T. Yoshino and S. Matsunaga, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC03072J

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