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Synthesis of biotin-labelled core glycans of GPI anchors and their application in the study of GPI interaction with pore-forming bacterial toxins

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Abstract

A convergent strategy was developed for the first-time synthesis of biotin-labeled GPI core glycans. These GPI conjugates are useful for various biological studies showcased by their application in the scrutiny of pore-forming bacterial toxin–GPI interaction, revealing that the phosphate group at the GPI inositol 1-O-position had a significant impact on GPI–toxin binding.

Graphical abstract: Synthesis of biotin-labelled core glycans of GPI anchors and their application in the study of GPI interaction with pore-forming bacterial toxins

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Publication details

The article was received on 20 Apr 2017, accepted on 15 May 2017 and first published on 15 May 2017


Article type: Communication
DOI: 10.1039/C7CC03056H
Citation: Chem. Commun., 2017, Advance Article
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    Synthesis of biotin-labelled core glycans of GPI anchors and their application in the study of GPI interaction with pore-forming bacterial toxins

    J. Gao, Z. Zhou, J. Guo and Z. Guo, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC03056H

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