Jump to main content
Jump to site search

Issue 46, 2017
Previous Article Next Article

Synthesis of biotin-labelled core glycans of GPI anchors and their application in the study of GPI interaction with pore-forming bacterial toxins

Author affiliations

Abstract

A convergent strategy was developed for the first-time synthesis of biotin-labeled GPI core glycans. These GPI conjugates are useful for various biological studies showcased by their application in the scrutiny of pore-forming bacterial toxin–GPI interaction, revealing that the phosphate group at the GPI inositol 1-O-position had a significant impact on GPI–toxin binding.

Graphical abstract: Synthesis of biotin-labelled core glycans of GPI anchors and their application in the study of GPI interaction with pore-forming bacterial toxins

Back to tab navigation

Supplementary files

Publication details

The article was received on 20 Apr 2017, accepted on 15 May 2017 and first published on 15 May 2017


Article type: Communication
DOI: 10.1039/C7CC03056H
Citation: Chem. Commun., 2017,53, 6227-6230
  •   Request permissions

    Synthesis of biotin-labelled core glycans of GPI anchors and their application in the study of GPI interaction with pore-forming bacterial toxins

    J. Gao, Z. Zhou, J. Guo and Z. Guo, Chem. Commun., 2017, 53, 6227
    DOI: 10.1039/C7CC03056H

Search articles by author

Spotlight

Advertisements