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Kit-like radiofluorinated biomolecule to controlled self-assembly of 18F nanoparticles for smart PET imaging application

Abstract

Kit-like 18F-fluorination method has been successfully applied to prepare an activatable probe 1 with good radiochemical yield and high specific activity. The probe has good in vitro stability and favorable cell membrane permeability. A controlled condensation reaction was initiated and self-assembly into nanoparticles occurred when the probe was in a reducing environment. Positron emission tomography (PET) imaging of biothiol level in living subjects was conveniently and precisely realized using this probe. The present study may provide a new platform for the development of “smart” PET tracers for tumor imaging.

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Publication details

The article was received on 20 Apr 2017, accepted on 14 May 2017 and first published on 19 May 2017


Article type: Communication
DOI: 10.1039/C7CC03040A
Citation: Chem. Commun., 2017, Accepted Manuscript
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    Kit-like radiofluorinated biomolecule to controlled self-assembly of 18F nanoparticles for smart PET imaging application

    J. Lin, W. Wang, K. Li, H. Huang, G. lv, Y. Peng, S. luo and L. qiu, Chem. Commun., 2017, Accepted Manuscript , DOI: 10.1039/C7CC03040A

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