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Issue 48, 2017
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Development of a kit-like radiofluorinated biomolecule leading to a controlled self-assembly of 18F nanoparticles for a smart PET imaging application

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Abstract

A kit-like 18F-fluorination method has been successfully applied to prepare an activatable probe 1 with good radiochemical yield and high specific activity. The probe has good in vitro stability and favorable cell membrane permeability. A controlled condensation reaction was initiated, and self-assembly into nanoparticles occurred when the probe was in a reducing environment. Positron emission tomography (PET) imaging of the biothiol level in living subjects was conveniently and precisely realized using this probe. The present study may provide a new platform for the development of “smart” PET tracers for tumor imaging.

Graphical abstract: Development of a kit-like radiofluorinated biomolecule leading to a controlled self-assembly of 18F nanoparticles for a smart PET imaging application

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Publication details

The article was received on 20 Apr 2017, accepted on 14 May 2017 and first published on 19 May 2017


Article type: Communication
DOI: 10.1039/C7CC03040A
Citation: Chem. Commun., 2017,53, 6476-6479
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    Development of a kit-like radiofluorinated biomolecule leading to a controlled self-assembly of 18F nanoparticles for a smart PET imaging application

    J. Lin, W. Wang, K. Li, H. Huang, G. Lv, Y. Peng, S. Luo and L. Qiu, Chem. Commun., 2017, 53, 6476
    DOI: 10.1039/C7CC03040A

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