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Issue 58, 2017
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Copper-catalyzed intermolecular asymmetric propargylic dearomatization of phenol derivatives

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Abstract

A copper-catalyzed intermolecular asymmetric propargylic dearomatization of phenol derivatives has been realized. Under the catalysis of Cu(OTf)·1/2C6H6 decorated with a chiral tridentate ketimine P,N,N-ligand, the dearomatization reaction proceeded smoothly with excellent control of chemo-, regio-, and enantioselectivities, thus providing a variety of optically active cyclohexadienone derivatives with up to >99% ee.

Graphical abstract: Copper-catalyzed intermolecular asymmetric propargylic dearomatization of phenol derivatives

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Publication details

The article was received on 20 Apr 2017, accepted on 29 Jun 2017 and first published on 29 Jun 2017


Article type: Communication
DOI: 10.1039/C7CC03034G
Citation: Chem. Commun., 2017,53, 8192-8195
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    Copper-catalyzed intermolecular asymmetric propargylic dearomatization of phenol derivatives

    L. Shao and X. Hu, Chem. Commun., 2017, 53, 8192
    DOI: 10.1039/C7CC03034G

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