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Issue 81, 2017
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Turning on the red phosphorescence of a [Ru(tpy)(bpy)(Cl)]Cl complex by amide substitution: self-aggregation, toxicity, and cellular localization of an emissive ruthenium-based amphiphile

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Abstract

Coupling the notoriously non-emissive complex [Ru(tpy)(bpy)Cl]Cl (tpy = 2,2′:6′,2′′-terpyridine, bpy = 2,2′-bipyridine) to a C12 alkyl chain via an amide linker on the 4′ position of the terpyridine yielded a new amphiphilic ruthenium complex showing red emission and chloride-dependent aggregation properties. This emissive complex is highly cytotoxic in A549 non-small lung cancer cells where it can be followed by confocal microscopy. Uptake occurs within minutes, first by insertion into the cellular membrane, and then by migration to the peri-nuclear region.

Graphical abstract: Turning on the red phosphorescence of a [Ru(tpy)(bpy)(Cl)]Cl complex by amide substitution: self-aggregation, toxicity, and cellular localization of an emissive ruthenium-based amphiphile

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Publication details

The article was received on 18 Apr 2017, accepted on 27 Jun 2017 and first published on 28 Jun 2017


Article type: Communication
DOI: 10.1039/C7CC02989F
Citation: Chem. Commun., 2017,53, 11126-11129
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    Turning on the red phosphorescence of a [Ru(tpy)(bpy)(Cl)]Cl complex by amide substitution: self-aggregation, toxicity, and cellular localization of an emissive ruthenium-based amphiphile

    B. Siewert, M. Langerman, Y. Hontani, J. T. M. Kennis, V. H. S. van Rixel, B. Limburg, M. A. Siegler, V. Talens Saez, R. E. Kieltyka and S. Bonnet, Chem. Commun., 2017, 53, 11126
    DOI: 10.1039/C7CC02989F

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