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Bis(trialkylsilyl) Peroxides as Alkylating Agents in the Copper-catalyzed Selective Mono-N-alkylation of Primary Amides

Abstract

The copper-catalyzed selective mono-N-alkylation of primary amides with bis(trialkylsilyl) peroxides as alkylating agents was reported. The results of a mechanistic study suggest that this reaction should proceed via a free radical process that includes the generation of alkyl radicals from bis(trialkylsilyl) peroxides.

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Publication details

The article was received on 15 Apr 2017, accepted on 16 May 2017 and first published on 19 May 2017


Article type: Communication
DOI: 10.1039/C7CC02910A
Citation: Chem. Commun., 2017, Accepted Manuscript
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    Bis(trialkylsilyl) Peroxides as Alkylating Agents in the Copper-catalyzed Selective Mono-N-alkylation of Primary Amides

    R. Sakamoto, S. Sakurai and K. Maruoka, Chem. Commun., 2017, Accepted Manuscript , DOI: 10.1039/C7CC02910A

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