Jump to main content
Jump to site search

Issue 48, 2017
Previous Article Next Article

Bis(trialkylsilyl) peroxides as alkylating agents in the copper-catalyzed selective mono-N-alkylation of primary amides

Author affiliations

Abstract

The copper-catalyzed selective mono-N-alkylation of primary amides with bis(trialkylsilyl) peroxides as alkylating agents was reported. The results of a mechanistic study suggest that this reaction should proceed via a free radical process that includes the generation of alkyl radicals from bis(trialkylsilyl) peroxides.

Graphical abstract: Bis(trialkylsilyl) peroxides as alkylating agents in the copper-catalyzed selective mono-N-alkylation of primary amides

Back to tab navigation

Supplementary files

Publication details

The article was received on 15 Apr 2017, accepted on 16 May 2017 and first published on 19 May 2017


Article type: Communication
DOI: 10.1039/C7CC02910A
Citation: Chem. Commun., 2017,53, 6484-6487
  •   Request permissions

    Bis(trialkylsilyl) peroxides as alkylating agents in the copper-catalyzed selective mono-N-alkylation of primary amides

    R. Sakamoto, S. Sakurai and K. Maruoka, Chem. Commun., 2017, 53, 6484
    DOI: 10.1039/C7CC02910A

Search articles by author

Spotlight

Advertisements