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Dual-channel signal for intracellular mRNA detection via a PRET nanosensor

Abstract

An intracellular nanosensor was designed and developed to accurately sense mRNA in the living cells without false positive results. This nanosensor consists of gold nanoparticles assembled with recognition sequences, and dye-labelled nanoflares. With analyzing both wavelength shifts and intensity recovery of the scattering spectra, this dual-channel nanosensor could efficiently distinguish and avoid the interference induced by other common substances. This novel dual-channel nanosensor would precisely recognize the target mRNA, and it is promising for further cancer diagnoses.

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Publication details

The article was received on 13 Apr 2017, accepted on 16 Jun 2017 and first published on 16 Jun 2017


Article type: Communication
DOI: 10.1039/C7CC02864D
Citation: Chem. Commun., 2017, Accepted Manuscript
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    Dual-channel signal for intracellular mRNA detection via a PRET nanosensor

    T. Xie, M. Li and Y. Long, Chem. Commun., 2017, Accepted Manuscript , DOI: 10.1039/C7CC02864D

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