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Issue 54, 2017
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Practical in situ-generation of phosphinite ligands for palladium-catalyzed carbonylation of (hetero)aryl bromides forming esters

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Abstract

An effective method for alkoxycarbonylation of (hetero)aryl bromides is developed in the presence of in situ-generated phosphinite ligands tBu2POR (R = nBu, nPr, Et or Me). For this purpose commercially available tBu2PCl was used as the pre-ligand in the presence of different alcohols. For the first time cross coupling reactions with two alcohols – one generating the ligand, the other used as substrate – were developed. Through this method, ligand optimization can be performed in a more efficient manner and the desired products could be obtained with good yields and selectivity.

Graphical abstract: Practical in situ-generation of phosphinite ligands for palladium-catalyzed carbonylation of (hetero)aryl bromides forming esters

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Publication details

The article was received on 12 Apr 2017, accepted on 09 Jun 2017 and first published on 12 Jun 2017


Article type: Communication
DOI: 10.1039/C7CC02828H
Citation: Chem. Commun., 2017,53, 7469-7472
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    Practical in situ-generation of phosphinite ligands for palladium-catalyzed carbonylation of (hetero)aryl bromides forming esters

    L. Wang, H. Neumann, A. Spannenberg and M. Beller, Chem. Commun., 2017, 53, 7469
    DOI: 10.1039/C7CC02828H

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