Jump to main content
Jump to site search


Identification of actin as a direct proteomic target of berberine using an affinity-based chemical probe and elucidation of its modulatory role in actin assembly

Author affiliations

Abstract

Despite the diverse pharmacological activities of berberine, including anti-cancer and anti-inflammatory effects, the direct proteomic targets of berberine have remained largely unknown. Here, we have identified actin as a direct proteomic target of berberine using an affinity-based chemical probe. In addition, we found that actin assembly was significantly modulated by berberine in vitro at the biochemical level and cellular level.

Graphical abstract: Identification of actin as a direct proteomic target of berberine using an affinity-based chemical probe and elucidation of its modulatory role in actin assembly

Back to tab navigation

Supplementary files

Publication details

The article was received on 11 Apr 2017, accepted on 07 Jun 2017 and first published on 07 Jun 2017


Article type: Communication
DOI: 10.1039/C7CC02789C
Citation: Chem. Commun., 2017, Advance Article
  •   Request permissions

    Identification of actin as a direct proteomic target of berberine using an affinity-based chemical probe and elucidation of its modulatory role in actin assembly

    C. Yi, J. Yu, H. Kim, N. Lee, S. W. Kim, N. Lee, J. Lee, J. Seong, N. Kim and K. Inn, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC02789C

Search articles by author

Spotlight

Advertisements